Cell Line Lysates
BD NIH 3T3 Cell Lysate
Used as a control for the western blotting application
BD Rat Spleen Lysate
Convenient to use and useful control for western blotting application
Cayman Chemical CItreoIndole 2.5mg
A potent and selective SIRT2 inhibitor (IC50s 0 028 98 200 and 200 M for SIRT2 SIRT1 SIRT3 and SIRT5-7 respectively) inhibits acetyl-H3K9 peptide and NAD binding to SIRT2 and promotes c-Myc degradation in a dose-dependent manner exhibits selective cytotoxicity (IC50s 8 4-36 8 and 50 M for cancerous and non-cancerous cell lines respectively) decreases tumor volume and increases areas of necrosis in an MDA-MB-231 mouse breast cancer xenograft model increases tumor-free survival time in a MMTV-PyMT mouse mammary tumor model
Cayman Chemical sPLA2mouse TYP V Blockng 200ug
A PI4KIIIa inhibitor (IC50 3 16 nM) selective for PI4KIIIa over PI4KIIIB PI3Ka PI3KB and PI3K (IC50s 50 nM) inhibits PI3KY (IC50 15 8 nM) decreases the levels of PtdIns-(4)-P1 in HEK293 cells expressing the AT1 receptor (IC50 3 nM) inhibits HCV genotype 1a and 1b replication
ATCC RAJI-LUC2
Raji-Luc2 CAR-T Target Luciferase Reporter Cells can be used as a target cancer cell for in vitro killing assay by CD19 CAR-T cells (tested at ATCC) and is expected to also work for CD20 CAR-T cells. Raji-Luc2 naturally expresses high levels of CD19 (verified at ATCC).
Cayman Chemical ProstaglndIn TrnsporterC 200ug
An epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo
Cayman Chemical CaveolIn13 Blockng PepID 200ug
An inhibitor of menin-MLL fusion protein interactions (IC50 446 nM) binds to menin (Kd 158 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells inhibits growth of mouse BMCs expressing the Hoxa9 transformation-dependent MLL-AF9 (GI50 5 UM) inhibits the growth of MV4 KOPN-8 ML-2 and MonoMac6 MLL cells expressing MLL fusion proteins (GI50s 9 5 7 2 8 7 and 18 M respectively)
ATCC Jurkat, Clone E6-1, Acute T Cell Leukemia, Frozen
Clone E6-1 cells produce large amounts of IL-2 after stimulation with phorbol esters and either lectins or monoclonal antibodies against the T3 antigen (both types of stimulants are needed to induce IL-2 production. New ATCC customers are required to register with ATCC prior to purchase. The application can be found at https://www.atcc.org/en/My_Profile/Register.aspx
Cayman Chemical A83016F 2.5mg
A DNA alkylating agent active metabolite of dacarbazine (DTIC) active degradation product of temozolomide cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65 respectively at 1 mM cytotoxic to TLX5 murine lymphoma cells induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks